Treatment: conduct a course of treatment with dexamethasone (10 mg every 12 hours for 3 days).
Precautions for the Tretinoin dosage substance.
In the case of inpatient treatment, it is carried out under the careful supervision of an oncologist or hematologist. Before treatment of leukemia it is necessary to perform cytogenetic examination to detect changes in chromosomes (in the absence of chromosome t(15; 17) translation and/or the corresponding transcript of PML/RAR-alpha). During treatment, cholesterol levels, triglycerides, leukocyte counts and liver function should be monitored. Adequate measures and facilities should be provided to diagnose and treat possible complications.
Acute leukemia relapse is possible after 2-4 weeks after treatment termination. Women (even with anamnestic indications of infertility) should use adequate contraceptive measures a month before, during and within a month after the course. Application begins on the 2nd-3rd day of the normal menstrual cycle. Absence of pregnancy should be confirmed by tretionin laboratory methods 2 weeks before the start of treatment, such tests should be performed at least once a month. It is necessary to abstain from using in pediatric practice, as the safety and effectiveness of its use in children are not determined. If there is a significant increase in the number of white blood cells in the blood to prevent "retinoic acid syndrome", the treatment should be combined with a full-dose course of chemotherapy (it is prescribed on the 5th day of treatment - with a total number of white blood cells 6-109/l, on the 10th day - with a total number of white blood cells 10-109/l, on the 15th day - with a total number of white blood cells 15-109/l and more, immediately - if the treatment is initiated against a background of increased white blood cell count of more than 10-109/l).
In case of external application, the treated skin areas should be protected from sunlight and artificial UV irradiation, wind, cold; patients with tanning should start the treatment after tanning mitigation. In case of contact with mucous membranes, rinse with water.